Tiamulin Fumarate Soluble Powder

For Veterinary Use Only

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Main Ingredient:

Tiamulin Fumarate

Specification:
10 g per 100 g

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Pharmacological Action:

Pharmacodynamics:
Tiamulin is a pleuromutilin-class antibiotic with bactericidal effects at high concentrations. It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit.

It is particularly effective against:

• Mycoplasma spp. (chronic respiratory disease in chickens, swine enzootic pneumonia)

• Brachyspira hyodysenteriae (swine dysentery)

• Lawsonia intracellularis (proliferative enteropathy)

• Actinobacillus pleuropneumoniae

• Staphylococcus and Streptococcus spp. (except group D)

When combined with chlortetracycline at a 1:4 ratio, it is effective in treating mixed infections such as bacterial enteritis and pneumonia in pigs.

Pharmacokinetics:

• Rapid absorption in pigs with ~85% oral bioavailability

• Peak plasma concentration in 2–4 hours

• Highest tissue concentration found in the lungs

• Metabolized into over 20 active and inactive compounds

• Excreted mainly via bile in feces, ~30% via urine

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Drug Interactions:

1. Incompatible with ionophores like monensin, salinomycin, and maduramicin – co-use can cause chicken growth retardation, ataxia, paralysis, or death.

2. Avoid concurrent use with macrolides or lincosamides, as they compete for the same ribosomal binding sites, possibly reducing efficacy.

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Indications:

Used for prevention and treatment of:

• Chronic respiratory disease (CRD) in chickens

• Swine enzootic pneumonia

• Swine pleuropneumonia

• Swine dysentery and proliferative enteropathy caused by Lawsonia intracellularis

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Dosage and Administration:

By drinking water:

• Pigs: 0.45–0.6 g per 1 L, for 5 consecutive days

• Chickens: 1.25–2.5 g per 1 L, for 3 consecutive days

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Adverse Reactions:

Occasional skin redness in pigs. Overdose may cause salivation, vomiting, and central nervous system depression.

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Precautions:

1. Do not use with ionophore antibiotics (e.g., monensin, salinomycin, maduramicin).

2. Avoid contact with skin and eyes during handling.

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Withdrawal Period:

• Pigs: 7 days

• Chickens: 5 days

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Packaging:

100 g/bag × 100 bags/carton

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