For Veterinary Use Only
Main Ingredient:
Florfenicol
Specification:
10% (100 ml/bottle × 60 bottles/carton)
Indications:
Used to treat poultry infections caused by florfenicol-sensitive bacteria, such as avian cholera, pullorum disease, and colibacillosis.
Pharmacological Action:
Pharmacodynamics:
Florfenicol is a broad-spectrum amphenicol antibiotic with potent activity against many Gram-positive, Gram-negative bacteria, and mycoplasma. It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit.
It remains effective against certain chloramphenicol-resistant strains due to lack of acetylation resistance (e.g., E. coli, Klebsiella pneumoniae). It shows strong efficacy against Pasteurella multocida, Haemophilus parasuis, and Actinobacillus pleuropneumoniae.
Pharmacokinetics:
After oral administration, florfenicol is rapidly absorbed, reaching therapeutic levels in about 1 hour and peak plasma concentration in 1–3 hours.
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Bioavailability: >80%
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Distribution: Wide tissue distribution; crosses the blood-brain barrier
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Excretion: Mainly via urine; partially via feces
Drug Interactions:
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Macrolides and lincosamides share the same binding site and may antagonize florfenicol.
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May also interfere with β-lactams and aminoglycosides (not yet confirmed in vivo).
Dosage and Administration:
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Drinking water: 1.0 – 1.5 ml per 1 L water for poultry
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Duration: 3–5 consecutive days
Adverse Reactions:
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May cause immunosuppression at high doses
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Has embryotoxic effects – avoid during pregnancy and lactation
Precautions:
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Do not use in laying hens during the laying period
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Reduce dose or extend dosing interval for animals with renal insufficiency
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Do not use during vaccination or in animals with severely compromised immune function
Withdrawal Period:
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Chickens: 5 days
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