Colistin Sulfate Soluble Powder

Colistin Sulfate Soluble Powder

Category:

For Veterinary Use Only

Main Ingredient:

Colistin Sulfate

Specification:
10 g per 100 g (300 million IU)

Pharmacological Action:

Pharmacodynamics:
Colistin is a polypeptide antibiotic and a cationic surfactant. It interacts with phospholipids in the bacterial cell membrane, disrupts membrane integrity, increases permeability, and causes bacterial death.
It shows potent bactericidal activity against Gram-negative aerobes such as:

  • Escherichia coli

  • Haemophilus spp.

  • Klebsiella spp.

  • Pasteurella spp.

  • Pseudomonas aeruginosa

  • Salmonella spp.

  • Shigella spp.

Gram-positive bacteria are generally resistant. Colistin has complete cross-resistance with polymyxin B, but not with other antibiotic classes.

Pharmacokinetics:

  • Poorly absorbed through oral administration

  • Rapidly absorbed via non-oral routes and widely distributed in organs such as the heart, lungs, liver, kidneys, and skeletal muscles

  • Primarily excreted unchanged via the kidneys

Drug Interactions:

  • May cause muscle weakness or respiratory arrest when combined with neuromuscular blockers or aminoglycosides

  • Shows synergistic effects with EDTA and cationic disinfectants against Pseudomonas aeruginosa

Indications:

For the treatment of intestinal infections in pigs and chickens caused by Gram-negative bacteria.

Dosage and Administration:

  • Drinking water:

    • Pigs: 0.4 – 2 g per 1 L

    • Chickens: 0.2 – 0.6 g per 1 L

  • Feed premix (pigs):

    • 0.4 – 0.8 g per 1 kg of feed

  • Duration: Up to 7 days

Adverse Reactions:

None observed when used according to recommended dosage.

Precautions:

  1. Not for use in laying hens producing eggs for human consumption.

  2. Do not use for more than one consecutive week.

Withdrawal Period:

  • Pigs and Chickens: 7 days

Packaging:

100 g/bag × 100 bags/carton

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